Triethylamine → HCID 23003068, compound

Participants

Reaction Steps

889 mg (4.074 mmol) of tert-butyl pyrocarbonate are added at 0° C. to a suspension of 1.20 g (3.395 mmol) of 5(2,6-dimethyl-4-nitrophenoxy)-3-pentyl-1H-indazole (Example XX), 378 mg (3.735 mmol) of triethylamine and 41 mg (0.340 mmol) of 4-dimethylaminopyridine in 5 ml of tetrahydrofuran and 5 ml of acetonitrile and the mixture is stirred at room temperature for 30 min. The reaction mixture is then freed from the solvent in vacuo, taken up with ethyl acetate, and the organic phase is washed once each with 1N hydrochloric acid, satd sodium hydrogencarbonate solution and satd. sodium chloride solution, dried over sodium sulphate, freed from the solvent in vacuo and purified on silica gel using methylene chloride. 1.57 g (92% of theory) of 1-tert-butoxycarbonyl-5-(2,6-dimethyl-4-nitrophenoxy)-3-pentyl-1H-indazole are obtained.

Provenance & Evidence