Ammonium Chloride → HCID 178440409, compound

Participants

Reaction Steps

A solution of 56 mg (0.113 mmol) of ethyl [5-(4-{[ethoxy(oxo)acetyl]amino}-2,6-dimethylphenoxy)-3-isopropyl-1H-indazol-1-yl](oxo)acetate in 6 ml of ethanol is treated with a spatula-tipful of sodium ethoxide and stirred at room temperature for 30 min. 5 ml of satd ammonium chloride solution are added, the aqueous phase is extracted 2× with ethyl acetate, and the combined organic phases are washed 1× with water, dried over sodium sulphate and concentrated in vacuo and dried. 28 mc, (63%) of ethyl ({3,5-dimethyl-4-[(3-propyl-1H-indazol-5-yl)oxy]phenyl}amino)(oxo)-acetate are obtained.

Provenance & Evidence