Trifluoroacetic acid → HCID 178442319, compound

Participants

Reaction Steps

A solution of 474 mg (0.905 mmol) of ethyl ({3,5-dimethyl-4-[(1-tert-butoxycarbonyl-3-pentylindazol-5-yl)oxy]phenyl]}amino)(oxo) acetate (Example 13) and 2.58 g (22.63 mmol) of trifluoroacetic acid in 30 ml of methylene chloride is stirred at room temperature overnight. The mixture is subsequently concentrated in vacuo and the residue obtained is purified on silica gel using cyclohexane/ethyl acetate 3:2. 391 mg (99% of theory) of ethyl-({3,5-dimethyl-4-[(3-pentyl-1H-indazol-5-yl)oxy]phenyl}amino)(oxo)acetate are obtained.

Provenance & Evidence