Potassium Iodide → Phthalimide

Participants

Reaction Steps

Compound 45 (500 mg) obtained in Example 1, N-{2-(p-toluenesulfonyloxy)ethyl}phthalimide (537 mg), potassium iodide (258 mg), and sodium hydrogen carbonate (131 mg) were stirred in dimethylformamide (8 ml) at 150° C. for 28 hours. The reaction mixture was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium hydrogen carbonate, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain 260 mg of phthalimide compound.

Provenance & Evidence