Bromine → HCID 23003182, compound

Participants

Reaction Steps

To a solution of 2-(2-ethyl-2H-[1,2,4]triazol-3-ylmethoxy)-5-methyl-8-phenylimidazo[1,2-d][1,2,4]triazine (205 mg, 0.61 mmol) in a mixture of carbon tetrachloride (100 ml) and chloroform (50 ml) was added bromine (34.2 μl, 0.67 mmol) dropwise. The mixture was stirred for 1 h, the solvent removed in vacuo and the residue recrystallised from a mixture of diethyl ether and methanol to give the title compound (160 mg). δH (400 MHz; d6-DMSO) 1.35 (3H, t, J 7.2), 3.15 (3H, d, J 6.6), 4.31 (2H, q, J 7.2), 5.72 (2H, s), 7.58 (3H, m), 7.98 (1H, s), 8.42 (2H, m); m/z (ES+) 414/416 (M++H).

Provenance & Evidence