Dibutyltin oxide → HCID 178478103, compound

Participants

Reaction Steps

To a solution of 4-[5-(2,6-dichlorobenzyloxy)indole-1-yl]butyronitrile (0.1 g, 0.28 mmol) in toluene (3 mL) was added azidotrimethylsilane (0.11 mL, 0.83 mmol) and dibutyltin oxide (0.021 g, 0.083 mmol). The reaction was refluxed for 16 h. The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography (silica gel, dichloromethane/methanol) to yield a white foaming solid (0.067 g, 59%). MS(ES) m/e 402.0 [M+H]+.

Provenance & Evidence