HCID 23003154, compound → HCID 23003156, compound

Participants

Reaction Steps

To a solution of 4-[5-(2,6-dichlorobenzyloxy)-2-hydroxymethyl-indol-1-yl]butyronitrile (1.73 g, 4.44 mmol) in CH2Cl2 (100 mL) was added MnO2 (3.09 g, 35.6 mmol) and the reaction was stirred at room temperature for 18 h. The reaction mixture was filtered through Celite and the filtrate was concentrated under reduced pressure. Purification by flash column chromatography (silica gel, ethyl acetate/hexane) yielded the desired aldehyde (1.25 g, 73%) as a white solid. MS(ES) m/e 387.0 [M+H]+.

Provenance & Evidence