HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodo-4-nitro-2-(trifluoromethyl)benzene → 4-Iodo-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodo-4-nitro-2-(trifluoromethyl)benzene | HCID 19261778 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Iodo-3-(trifluoromethyl)aniline | HCID 23003624 | — |
Reaction Steps
In the presence of 1.7 g of Raney nickel, 8.6 g (27 mmol) of 4-iodo-3-trifluoromethyl-nitro-benzene are hydrogenated in 170 ml of methanol. The reaction mixture is filtered over Celite. Concentration of the filtrate by evaporation yields the oily title compound, which slowly crystallises when left to stand: 1H NMR (CDCl3) 7.63 (d, 1H), 6.98 (d, 1H), 6.54 (dd, 1H), 5.75 (s, H2N); FAB-MS (M+H)+=288.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06608071B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-ed12089089dc4fa88d414d1b36a86651 |
| Source note | uspto-grants-2003_08 |