Dimethylformamide → N-(3-aminosulfonyl-4-chloro-2-hydroxyphenyl)-N'-(1,3-dimethylpyrazol-5-yl)urea

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Reaction Steps

Under Ar, a solution of 3-amino-6-chloro-2-hydroxybenzenesulfonamide (137 mg, 0.61 mmol) and 5-(azidocarbonyl)-1,3-dimethylpyrazole (203 mg, 1.23 mmol) in 2 mL of N,N-dimethyl-formamide was stirred at room temperature for 3 days. Purification upon Gilson HPLC, eluting with acetonitrile/water (10/90, v/v to 90/10, v/v, over 10 min), gave the desired product (17 mg, 7.7%). LC-MS (m/z) 360.2 (M+).

Provenance & Evidence