Triethylamine → HCID 10207464, compound

Participants

Reaction Conditions

Reaction Steps

Under Ar, the mixture of 3-(benzyloxy)thieno[2,3-b]pyridine-2-carboxylic acid (150 mg, 0.53 mmol) in 2 mL of N,N-dimethyl-formamide was heated to 80° C. Diphenylphosphoryl azide (146 mg, 0.53 mmol), 3-amino-6-chloro-2-hydroxybenzenesulfonamide (117 mg, 0.53 mmol) and triethyl amine (0.054 mL, 0.53 mmol) were added. The resulting mixture was heated for another 18 hours. when kept temperature at 70° C. Purification upon Gilson HPLC, eluting with acetonitrile/water (10/90, v/v to 90/10, v/v, over 10 min), gave the desired product (70 mg, 26%). LC-MS (m/z) 505.2 (M+).

Provenance & Evidence