HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-hydroxy-3-isobutylpiperidine → HCID 21973782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-hydroxy-3-isobutylpiperidine | HCID 23003697 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | HCID 21973782 | HCID 21973782 | — |
Reaction Steps
A mixture of 1-benzyl-4-hydroxy-3-isobutylpiperidine (0.63 g, 2.5 mmole) and 20% palladium hydroxide (0.1 g) in methanol (20 ml) was stirred in hydrogen atmosphere (1 atm.) for 48 hr at 35° C. Catalyst was filtered off, washed with methanol, filtrate was concentrated to dryness to give 4-hydroxy-3-isobutylpiperidine as oil. Yield 0.35 g (91%), C9H19NO, m/z 158 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06608078B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-03d6d9f5b0ab4494b103241c2920734f |
| Source note | uspto-grants-2003_08 |