HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine → 3,5-Dimethyl-3-ethyl-4-hydroxypiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine | HCID 23003691 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | 3,5-Dimethyl-3-ethyl-4-hydroxypiperidine | HCID 23003680 | — |
Reaction Steps
A mixture of 1-benzyl-3,5-dimethyl-3-ethyl-4-hydroxypiperidine (2.9 g, 11.74 mmole) and 20% palladium hydroxide (0.5 g) in methanol (20 ml) was stirred in hydrogen atmosphere (1 atm.) for 8 hr at 35° C. Catalyst was filtered off, washed with methanol, filtrate was concentrated to dryness to give 3,5-dimethyl-3-ethyl-4-hydroxypiperidine as oil. Yield 1.7 g (93%), C9H19NO, m/z 158 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06608078B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-ab6dfa7b91e8455d9e544d86e4d60c23 |
| Source note | uspto-grants-2003_08 |