HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → (R,S)-N-(alpha-(1-Hydroxyethyl)benzyl]-3-methyl-2-phenylquinoline-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Amino-1-phenylpropan-2-ol | HCID 12352922 | — |
| Reactant | 3-Methyl-2-phenylquinoline-4-carbonyl chloride | HCID 22714326 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (R,S)-N-(alpha-(1-Hydroxyethyl)benzyl]-3-methyl-2-phenylquinoline-4-carboxamide | HCID 131720840 | — |
Reaction Steps
Prepared as described in Ex. 1, starting from 11.08 g ( 39.33 mmol) of crude 3-methyl-2-phenylquinoline-4-carbonylchloride, 4.87 g (32.20 mmol) of 1-phenyl-2-hydroxypropylamine and 10.33 ml (74.14 mmol) of TEA in 150 ml of a 1:1 mixture of dry CH2Cl2 and CH3CN.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06608083B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-6218c205ecd747b68d5ed3b4ec825f74 |
| Source note | uspto-grants-2003_08 |