Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 86586314 | HCID 86586314 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86586313 | HCID 86586313 | 73.4% |
Reaction Steps
To the mesylate from Example 2 (0.95 g, 1.78 mmols) in DMF (25 mL) was added sodium azide (0.47 g, 7.23 mmols) and heated to 70° C. for 16 hrs. After cooling to rt water was added and the mixture extracted with ethyl acetate (6×25 mL), washed with brine (4×10 mL), dried over Na2SO4, concentrated to give 0.48 g of a tan solid. MS (M+1)=354 m/z.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06608081B2 |
|---|
| Source dataset | uspto-grants-2003_08 |
|---|
| ORD ID | ord-0e57f1d41ca0484d828487c0a40fc83d |
|---|
| Source note | uspto-grants-2003_08 |
|---|
