Hydrochloric Acid → HCID 23004033, compound

Participants

Reaction Steps

To N-Benzyl-N-tert-butoxycarbonyl-β-methoxy-2,8-bis(trifluoromethyl)-4-quinolineethanamine (113 mg, 0.21 mmol) in dioxan (1 mL) was added HCl (4-M in dioxan, 0.25 mL, 1 mmol) and the mixture stirred at room temperature for 1 h. The mixture was concentrated in vacuo, triturated with ether and filtered to give the title compound (54 mg, 60%) as a white solid: mp 232-233° C.; NMR δH (400 MHz, DMSO-d6) 3.17-3.41 (2H, m), 3.34 (3H, s), 4.19 (1H, d, J 13.8 Hz), 4.22 (1H, d, J 13.8 Hz), 5.78 (1H, dd, J 9.26, 2.1 Hz), 7.36-7.46 (3H, m), 7.53-7.62 (2H, m), 8.00 (1H, t, J 8.0 Hz), 8.03 (1H, s), 8.42 (1H, d, J 7.7 Hz), 8.80 (1H, d, J 8.62 Hz); Anal. Calcd for C21H18F6N2O.HCl: C, 54.26; H, 4.12; N, 6.02. Found C, 54.04; H, 4.30; N, 5.79.

Provenance & Evidence