Bromine → HCID 87957976, compound

Participants

Reaction Steps

4-Fluoro-2-(2-fluoropyridin-4-yl)acetophenone (0.5 g; 2.1 mmol) dissolved in acetic acid (4 ml) is treated with bromine (0.34 g; 2.1 mmol) in acetic acid (1 ml) at room temperature for 2.5 h under stirring. The light brown solution is evaporated to dryness, dissolved in ether and extracted three times with diethyl ether. The combined organic phases are washed with a saturated solution of NaHCO3, dried over Na2SO4, filtered and evaporated to dryness to yield the title compound as pale yellow oil (0.67 g; 100%).

Provenance & Evidence