Tributylvinyltin → 2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-vinylimidazo[4,5-b]pyridine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Tributylvinyltin	HCID 81998	—
Edukt	5-Chloro-2-(4-fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)imidazo[4,5-b]pyridine	HCID 22486152	—
Katalysator	HCID 178418476	HCID 178418476	—
Lösungsmittel	O-Xylene	HCID 7237	—
Produkt	2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-vinylimidazo[4,5-b]pyridine	HCID 22486133	87,4%

Reaktionsbedingungen

Temperatur	160 °C

Reaktionsschritte

2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-chloroimidazo[4,5-b]pyridine (50 mg 0.12 mmol), vinyltributylstannane (4.3 ml 0.15 mmol) and PdCl2(PPh3)2 (8.6 mg 0.01 mmol) are dissolved in xylene (1 ml) and heated to 160° C. for 1 h under argon. The reaction mixture is purified over SiO2 (acetone/hexanes 15/85) to yield the title compound as colorless crystals (42 mg 86%)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06608072B1
Quelldatensatz	uspto-grants-2003_08
ORD ID	ord-fc813a0ea39c43709d727a5df67106ae
Quellennotiz	uspto-grants-2003_08