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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 396435Generated: October 27, 2026

2-Bromo-1-(5-methyl-2-pyridyl)ethanone → [6-Chloro-2-(5-methylpyridine-2-carbonyl)-1H-indol-3-yl]acetic Acid

https://huagongshe.com/reaction/396435

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-(5-methyl-2-pyridyl)ethanoneHCID 17801477—
ReactantMethyl trans-4-chloro-2-(ethoxycarbonylamino)cinnamateHCID 23003310—
Product[6-Chloro-2-(5-methylpyridine-2-carbonyl)-1H-indol-3-yl]acetic AcidHCID 9862268—

Reaction Steps

Two diastreomers of the title compound were prepared according the procedure described in step 2 of Example 31 from methyl trans-4-chloro-2-(ethoxycarbonylamino)cinnamate (Example 31, step 1) and 2-bromoacetyl-5-methylpyridine.*

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06608070B1
Source datasetuspto-grants-2003_08
ORD IDord-cd755beaa2024e1a80b4b52d53baf14f
Source noteuspto-grants-2003_08