Triethylamine → HCID 12094934, compound

Participants

Reaction Steps

To a solution of (2-benzoyl-6-chloro-1H-indol-3-yl)acetic acid (Example 2, 140 mg, 0.45 mmol), dimethylamine hydrochloride (45 mg, 0.54 mmol) and triethylamine (0.1 ml, 0.54 mmol) in DMF (2 ml) at 0° C. was added diethyl phosphorocyanidate (DEPC, 0.1 ml, 0.54 mmol). The mixture was then stirred at room temperature for 1 h. The mixture was poured into water (20 ml) and extracted with diethyl ether (50 ml×2). The organic extracts were washed with water (30 ml×2), dried (MgSO4) and concentraied. The residual solids were recrystallized from ethyl acetate/hexane to afford 50 mg (33%) of the title compound.

Provenance & Evidence