2-Bromo-5-chloropyridine → 2-Bromo-1-(5-chloropyridin-2-yl)ethanone

HRID 396474Notes

Reaction equation

HRID 396474 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Br:9][CH2:10][C:11](C1C=CC(C)=CN=1)=[O:12]>>[Br:9][CH2:10][C:11]([C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1)=[O:12]

Participants

3

Reactant 2

HCID 8170982-Bromo-5-chloropyridineHCID 178014772-Bromo-1-(5-methyl-2-pyridyl)ethanone

Product 1

HCID 111839252-Bromo-1-(5-chloropyridin-2-yl)ethanone

Procedure

* 2-Bromoacetyl-5-chloropyridine was prepared from 2-bromo-5-chloropyridine (Case, J. Am. Chem. Soc., 1946, 68, 2574) according to the procedure for preparing 2-bromoacetyl-5-methylpyridine described in step 1 of Example 32.

Sources & evidence

ORD record
ord-32671d0a644641debd99c2ca1497d03e
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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