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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 396479Generated: October 30, 2026

Methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate → Methyl[6-chloro-2-[4-(hydroxymethyl)pyridine-2-carbonyl]-1h-indol-3-yl]acetate

https://huagongshe.com/reaction/396479

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl trans-4-chloro-2-(phenylsulfonylamino)cinnamateHCID 11371593—
Reactant2-Bromoacetyl-4-(tert-butyldimethylsilyloxymethyl)pyridineHCID 23003580—
ProductMethyl[6-chloro-2-[4-(hydroxymethyl)pyridine-2-carbonyl]-1h-indol-3-yl]acetateHCID 23003608—

Reaction Steps

The title compound was prepared according to the procedure described in Example 57 from methyl trans-4-chloro-2-(penylsulfonylamino)cinnamate (step 1 of Example 8, Method A) and 2-bromoacetyl-4-(tert-butyldimethylsilyloxymethyl)pyridine*.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06608070B1
Source datasetuspto-grants-2003_08
ORD IDord-d811c636912d45738de95b9e765e1c21
Source noteuspto-grants-2003_08