1-(4-Chloro-pyridin-2-yl)-ethanone → 1-(3,4-Dimethylpyridin-2-YL)ethanone

HRID 396483Notes

Reaction equation

HRID 396483 reaction equation
[C:1]([C:4]1[CH:9]=[C:8]([CH3:10])[C:7](C)=[CH:6][N:5]=1)(=[O:3])[CH3:2].[CH3:12]C1C(C#N)=NC=CC=1C.CC1C(C)=CN=C(C#N)C=1.C(C1C=C(Cl)C=CN=1)(=O)C>>[C:1]([C:4]1[C:9]([CH3:12])=[C:8]([CH3:10])[CH:7]=[CH:6][N:5]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 4

HCID 130119861-(4-Chloro-pyridin-2-yl)-ethanoneHCID 132444834,5-Dimethylpyridine-2-carbonitrileHCID 230034093,4-Dimethylpyridine-2-carbonitrileHCID 230034311-(4,5-Dimethyl-2-pyridinyl)ethanone

Product 1

HCID 230034571-(3,4-Dimethylpyridin-2-YL)ethanone

Procedure

The title compound was prepared along with 2-acetyl-4,5-dimethylpyridine from 3,4-dimethylpyridine-2-carbonitrile including 4,5-dimethylpyridine-2-carbonitrile in the ratio of 5.5 to 1 according to the procedure for preparing 2-acetyl-4-chloropyridine described in Example 33.

Sources & evidence

ORD record
ord-f85dcbc30375423f9aeb4496baaeec03
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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