Methyl[6-chloro-2-(3-benzyloxybenzoyl)-1h-indol-3-yl]acetate → Methyl[6-chloro-2-(3-hydroxybenzoyl)-1h-indol-3-yl]acetate

Participants

Reaction Steps

A mixture of methyl[6-chloro-2-(3-benzyloxybenzoyl)-1H-indol-3-yl]acetate (Example 177, 0.37 g, 0.85 mmol) and 10% palladium-charcoal (80 mg) in ethyl acetate-methanol (5:1, 30 ml) was stirred under hydrogen atmosphere for 2.5 h. The mixture was filtered thorough a pad of Celite and the filtrate was concentrated. The solids were washed with dichloromethane (10 ml) to afford 70mg (24%) of the title compound as white solids.

Provenance & Evidence