1-(1,1'-Biphenyl)-4-yl-2-bromoethanone → Methyl[6-chloro-2-(4-phenylbenzoyl)-1h-indol-3-yl]acetate

HRID 396516Notes

Reaction equation

HRID 396516 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[C:8]([O:10][CH3:11])=[O:9])=[C:4]([NH:14]S(C2C=CC=CC=2)(=O)=O)[CH:3]=1.[C:24]1([C:30]2[CH:39]=[CH:38][C:33]([C:34](=[O:37])[CH2:35]Br)=[CH:32][CH:31]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:11][O:10][C:8](=[O:9])[CH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=2)[NH:14][C:35]=1[C:34](=[O:37])[C:33]1[CH:38]=[CH:39][C:30]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 672821-(1,1'-Biphenyl)-4-yl-2-bromoethanoneHCID 11371593Methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate

Product 1

HCID 23003244Methyl[6-chloro-2-(4-phenylbenzoyl)-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans 4-chloro-2-(phenylsulfonylamino)cinnamate (step 1 of Example 8, Method A) and 4-phenylphenacyl bromide.

Sources & evidence

ORD record
ord-37f54ff619754772952d3f82e325f586
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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