Bromine → 2-Bromo-1-(4-methyl-1,2,3-thiadiazol-5-yl)ethanone

Participants

Reaction Steps

To a solution of 5-acetyl-4-methyl-1,2,3-thiadiazole (1.00 g, 7.03 mmol) in chloroform (20 ml) was added dropwise a solution of bromine (1.24 g, 7.73 mmol) in chloroform (10 ml) over 0.5 h at room temperature. The mixture was heated at reflux temperature for 2 h. After cooling to room temperature, the mixture was made basic with saturated aqueous sodium bicarbonate and extracted with dichloromethane (100 ml×2). The extracts were dried (Na2SO4) and concentrated to give 1.55 g (100%) of the title compound as a brown oil.

Provenance & Evidence