Trimethylsilyldiazomethane → Methyl[6-chloro-2-(1-methylimidazole-2-carbonyl)-1h-indol-3-yl]acetate

Participants

Reaction Steps

To a stirred solution of [6-chloro-2-(1-methylimidazole-2-carbonyl)indol-3-yl]acetic acid (Example 241, 65 mg, 0.21 mmol) in methanol (10 ml) was added (trimethylsilyl)diazomethane (1.0 M solution in hexanes, 1.05 ml, 2.1 mmol) at room temperature. After stirring for 19 h, the mixture was concentrated. The residue was purified by TLC developing with ethyl acetate-hexane (1:2) to afford 20 mg (23%) of the title compound as yellow solids.

Provenance & Evidence