Hydrochloric Acid → HCID 23003453, compound

Participants

Reaction Steps

To a solution of methyl[5-chloro-2-[1-[2-(trimethylsilyl)ethoxymethyl]imidazole-2-carbonyl]-1H-indol-3-yl]acetate (step 1, 300 mg, 0.67 mmol) in methanol (10 ml) was added 2N aqueous HCl (7 ml) and the mixture was refluxed for 1.5 h. After cooling to room temperature, the mixture was concentrated. To the residue was added saturated aqueous sodium bicarbonate (10 ml ) and then the mixture was concentrated. The residual yellow solids were dissolved in THF (100 ml) and dried (MgSO4). Removal of solvent afforded 220 mg (100%) of the title compound as yellow solids.

Provenance & Evidence