Hydrochloric Acid → HCID 23003230, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl[5-chloro-2-[3-(ethoxycarbonyl)isoxazole-5-carbonyl]-1H-indol-3-yl]acetate (Example 259, 314 mg, 0.80 mmol) in acetic acid (20 ml) was added 2N aqueous HCl (6.0 ml) and the mixture was heated at 110° C. for 5 h. The mixture was then cooled to room temperature and concentrated. The residual yellow solids were washed with ethyl acetate and recrystallized from ethyl acetate/hexane to afford 120 mg (43%) of the title compound as pale yellow solids.

Provenance & Evidence