2-Bromo-1-cyclobutylethan-1-one → Methyl[6-chloro-2-cyclobutanecarbonyl-1h-indol-3-yl]acetate

HRID 396560Notes

Reaction equation

HRID 396560 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[C:8]([O:10][CH3:11])=[O:9])=[C:4]([NH:14]S(C2C=CC=CC=2)(=O)=O)[CH:3]=1.[CH:24]1([C:28]([CH2:30]Br)=[O:29])[CH2:27][CH2:26][CH2:25]1>>[CH3:11][O:10][C:8](=[O:9])[CH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=2)[NH:14][C:30]=1[C:28]([CH:24]1[CH2:27][CH2:26][CH2:25]1)=[O:29]

Participants

3

Reactant 2

HCID 110629402-Bromo-1-cyclobutylethan-1-oneHCID 11371593Methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate

Product 1

HCID 23003413Methyl[6-chloro-2-cyclobutanecarbonyl-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-4-chloro-2-(phenylsulfonylamino)cinnamate (step 1 of Example 8, Method A) and bromomethyl cyclobutyl ketone*.

Sources & evidence

ORD record
ord-627c0dca1e8548c0a2eda61b7e1286f2
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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