p-Chlorophenacyl bromide → Methyl[5-(tert-butyl)-2-(4-chlorobenzoyl)-1h-indol-3-yl]acetate

HRID 396561Notes

Reaction equation

HRID 396561 reaction equation
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:17]S(C2C=CC(C)=CC=2)(=O)=O)=[C:9]([CH:16]=1)/[CH:10]=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])([CH3:4])([CH3:3])[CH3:2].[Cl:28][C:29]1[CH:38]=[CH:37][C:32]([C:33](=[O:36])[CH2:34]Br)=[CH:31][CH:30]=1>>[CH3:15][O:14][C:12](=[O:13])[CH2:11][C:10]1[C:9]2[C:8](=[CH:7][CH:6]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[CH:16]=2)[NH:17][C:34]=1[C:33](=[O:36])[C:32]1[CH:37]=[CH:38][C:29]([Cl:28])=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 68303p-Chlorophenacyl bromideHCID 23003394Methyl trans-5-tert-butyl-2-(p-toluenesulfonylamino)cinnamate

Product 1

HCID 23003363Methyl[5-(tert-butyl)-2-(4-chlorobenzoyl)-1h-indol-3-yl]acetate

Procedure

The title compound was prepared according to the procedure described in Example 57 from methyl trans-5-tert-butyl-2-(p-toluenesulfonylamino)cinnamate (Example 143, step 2) and 4-chlorophenacyl bromide.

Sources & evidence

ORD record
ord-027317ece64d4d9fa52ac0146ae93e23
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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