N-BOC-ethylenediamine → [5-Chloro-2-(4-methylpyridine-2-carbonyl)-1H-indol-3-yl]-N-(2-aminoethyl)acetamide

HRID 396564Notes

Reaction equation

HRID 396564 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1)=[O:12])=[C:5]2[CH2:20][C:21](O)=[O:22].C(OC(=O)[NH:30][CH2:31][CH2:32][NH2:33])(C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1)=[O:12])=[C:5]2[CH2:20][C:21]([NH:30][CH2:31][CH2:32][NH2:33])=[O:22]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 23003314[5-Chloro-2-(4-methylpyridine-2-carbonyl)-1H-indol-3-yl]acetic Acid

Product 1

HCID 23003514[5-Chloro-2-(4-methylpyridine-2-carbonyl)-1H-indol-3-yl]-N-(2-aminoethyl)acetamide

Procedure

The title compound was prepared according to the procedure described in Example 43 from [5-chloro-2-(4-methylpyridine)-1H-indol-3-yl]acetic acid (Example 36) and N-(2-aminoethyl)carbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-9ab6fc4241e943849f12baeea2dde5f6
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

Loading…