tert-butyl N-(pyrrolidin-3-yl)carbamate → 5-Chloro-2-(4-methylpyridine-2-carbonyl)-1H-indol-3-yl-1-(3-amino-1-pyrrolidinyl)-1-ethanone

HRID 396565Notes

Reaction equation

HRID 396565 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1)=[O:12])=[C:5]2[CH2:20][C:21](O)=[O:22].C(OC([NH:31][CH:32]1[CH2:36][CH2:35][NH:34][CH2:33]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1)=[O:12])=[C:5]2[CH2:20][C:21]([N:34]1[CH2:35][CH2:36][CH:32]([NH2:31])[CH2:33]1)=[O:22]

Participants

3

Reactant 2

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 23003314[5-Chloro-2-(4-methylpyridine-2-carbonyl)-1H-indol-3-yl]acetic Acid

Product 1

HCID 230034015-Chloro-2-(4-methylpyridine-2-carbonyl)-1H-indol-3-yl-1-(3-amino-1-pyrrolidinyl)-1-ethanone

Procedure

The title compound was prepared according to the procedure described in Example 43 from [5-chloro-2-(4-methylpyridine)-1H-indol-3-yl]acetic acid (Example 36) and 3-(tert-butoxycarbonylamino)pyrrolidine.

Sources & evidence

ORD record
ord-d1e38cb265fa4dc18b2040ba2bb035f1
Source dataset
uspto-grants-2003_08
Patent number
US06608070B1

Reaction notes

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