Methanol → HCID 23003911, compound

Participants

Reaction Steps

A mixture of ethyl (R/S) 3-(1-{[4-(3-o-tolyl-ureido)-phenyl]-acetyl}-2,3-dihydro-1H-indol-5-yl)-butyrate [0.55 g, Reference Example 4(b)], aqueous sodium hydroxide solution (5.5 ml, 1M), methanol (5.5 ml) and tetrahydrofuran (11 ml) was stirred at room temperature overnight then evaporated to low bulk. The residue was diluted with water and the mixture was acidified by the addition of hydrochloric acid. The precipitate was collected by filtration, washed with water and then dried to give the title compound (0.41 g) as a white powder. LC-MS: RT=3.77 minutes (100% total area by ELS); MS (ES+) 472 (MH+), 494 (MNa+).

Provenance & Evidence