Sodium Sulfite → 3-Hydroxymethyl-4-(methylsulfonyl)nitrobenzene

Participants

Reaction Steps

To a solution of 3-hydroxymethyl-4-(methylthio)nitrobenzene from step 1 (20 g, 0.10 mol) in CH2Cl2 (500 mL) and MeOH (100 mL), m-CPBA (74 g, 0.30 mol) was added portionwise at 0° C., and the mixture was stirrred for 16 h at room temperature. The mixture was added aqueous Na2SO3 (20 g in 200 mL of water) at 0° C. Organic layer was separated and washed with saturated aqueous NaHCO3 (300 mL), dried over MgSO4, and concentarted in vacuo gave the title compound (15.6 g, 65%).

Provenance & Evidence