Bromine → HCID 53712477, compound

HRID 396846Notes

Reaction equation

HRID 396846 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17][CH3:18])=[CH:13][CH:12]=2)=[O:10])=[CH:4][CH:3]=1.[Br:19]Br>C(O)(=O)C.Br.C(O)(=O)C.CCOCC>[Br:19][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([S:17][CH3:18])=[CH:13][CH:12]=1)=[O:10]

Participants

6

Reactant 2

HCID 24408BromineHCID 114500672-(4-Bromophenyl)-1-[4-(methylthio)phenyl]ethanone

Product 1

HCID 53712477HCID 53712477, compoundYield 73%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 3283Diethyl EtherSolventHCID 21893785Acetic Acid Mixture with Hydrobromic AcidSolvent

Procedure

To a stirred suspension of 2-(4-bromophenyl)-1-(4-methylthiophenyl)ethanone from step1 (8.4 g, 0.024 mol) in acetic acid (130 mL), bromine (3.8 g, 0.024 mol) in 25% hydrogen bromide-acetic acid solution (50 mL) was added dropwise at room temperature. After stirring for 4 h at room temperature, concentrated gave the yellow solid. The solid was suspended in ether and collected by filtration, washed with ether to give the title compound (7.5 g, 73%).

Workup

  1. concentrationconcentrated
  2. customgave the yellow solid
  3. filtrationcollected by filtration
  4. washwashed with ether

Sources & evidence

ORD record
ord-c4bd5ce440a84ee981ca1e6e284d3f08
Source dataset
uspto-grants-2003_08
Patent number
US06608095B2

Reaction notes

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