4-Bromobenzoyl chloride → 2-(4-Bromophenyl)-1-(3-fluorophenyl)-1-ethanone

HRID 396855Notes

Reaction equation

HRID 396855 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[Br:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Br)=[CH:14][CH:13]=1.BrC1C=CC(C(Cl)=O)=CC=1.BrCC1C=CC(SC)=C(F)C=1>>[Br:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][C:5]([C:4]2[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)=[O:6])=[CH:14][CH:13]=1

Participants

5

Reactant 4

HCID 685154-Bromobenzoyl chlorideHCID 685274-Bromobenzyl bromideHCID 743763-Fluorobenzoyl chlorideHCID 223168194-(Bromomethyl)-2-fluoro-1-(methylsulfanyl)benzene

Product 1

HCID 223169002-(4-Bromophenyl)-1-(3-fluorophenyl)-1-ethanone

Procedure

The title compound was prepared according to the procedure of Example 169 step 3 using 3-fluorobenzoyl chloride and 4-bromobenzylbromide, instead of 4-bromobenzoyl chloride and 4-(bromomethyl)-2-fluoro-1-(methylsulfanyl)benzene.

Sources & evidence

ORD record
ord-59ac1aa1cd5448f0ba18edda92ae662d
Source dataset
uspto-grants-2003_08
Patent number
US06608095B2

Reaction notes

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