HRID396893

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1

HCID97370

Benzoyl-L-phenylalanine

C16H15NO3

结构：Cc1ccc(S(=O)(=O)N[C@@H](CCCCNC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1

HCID3013740

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)N(CC(C)C)[C@@H](CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2)C(=O)O)cc1

HCID508573

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from solid phase bound Nα-isobutyl-N(-(4-methylbenzenesulfonyl)-Nε-(9-fluorenylmethoxycarbonyl)-L-lysine as described in general procedure Bb using Nα-benzoyl-L-phenylalanine (321 mg, 1.2 mmol). The final product was purified by preparative HPLC to yield 44 mg (58%) of the desired material.

WORKUP

后处理

customThe final product was purified by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aead5722998e416893f2ea4bbf3ccbd1
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06608100B1
来源说明: uspto-grants-2003_08

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@H:12]([C:35]([OH:37])=[O:36])[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]([O:20]CC2C3C=CC=CC=3C3C2=CC=CC=3)=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:38]([NH:46][C@H:47](C(O)=O)[CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)(=[O:45])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]([C@H:12]([C:35]([OH:37])=[O:36])[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]([C@@H:47]([NH:46][C:38]([C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)=[O:45])[CH2:48][C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)=[O:20])[CH2:1][CH:2]([CH3:7])[CH3:3])(=[O:9])=[O:10])=[CH:6][CH:7]=1