L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → (2S)-6-[[(2S,3R)-3-benzyloxy-2-(tert-butoxycarbonylamino)butanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid

Participants

Reaction Steps

The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using commercially available Nα-tert-butoxycarbonyl-O-benzyl-L-threonine (93 mg, 0.3 mmol). The final product was triturated with ether to yield 195 mg (98%) of the desired material.

Provenance & Evidence