1-Bromohexane → Ethyl 3-[4-benzyloxyphenyl]-2-hexyloxypropanoate

HRID 396931Notes

Reaction equation

HRID 396931 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([OH:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 81011-BromohexaneHCID 151861533-(4-Benzyloxyphenyl)-2-hydroxypropionic acid ethyl ester

Product 1

HCID 21930969Ethyl 3-[4-benzyloxyphenyl]-2-hexyloxypropanoateYield 22.3%

Procedure

The title compound (1.2 g, 22%) was prepared as an oil from ethyl 3-(4-benzyloxyphenyl)-2-hydroxypropanoate (4.2 g, 14.0 mmol) and 1-bromohexane (3.4 g, 21.0 mmol) by an analogous procedure to that described in preparation 5.

Workup

  1. customthat described in preparation 5

Sources & evidence

ORD record
ord-096f4aecd9314d298d018104d9ea939c
Source dataset
uspto-grants-2003_08
Patent number
US06608194B1

Reaction notes

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