HCID 67537704, compound → HCID 59398084, compound

HRID 39694Notes

Reaction equation

HRID 39694 reaction equation
[CH:1]1([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([CH3:24])=[CH:12][C:13](=[O:23])[N:14]3[CH2:17][CH:18]3[O:22][CH2:21][CH2:20][O:19]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]1.C1(C2C=C3C(C(C)=CC(=O)N3CC3OCCO3)=CC=2)CCCCC=1>[C].[Pd].C(O)C>[CH:1]1([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([CH3:24])=[CH:12][C:13](=[O:23])[N:14]3[CH2:17][CH:18]3[O:19][CH2:20][CH2:21][O:22]3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 67537704HCID 67537704, compoundHCID 67539037HCID 67539037, compound

Product 1

HCID 59398084HCID 59398084, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To 5 mL of an ethanol solution containing 0.39 g of the mixture of 7-(2-cyclohexen-1-yl)-1-(1,3-dioxolan-2-ylmethyl)-4-methylquinolin-2(1H)-one and 7-(1-cyclohexen-1-yl)-1-(1,3-dioxolan-2-ylmethyl)-4-methylquinolin-2(1H)-one, 0.12 g of 5% palladium carbon was added, the mixture was stirred at room temperature for 1 hour and 30 minutes under a hydrogen atmosphere. The insoluble material filtered off, and the solvent was removed under reduced pressure to obtain 0.31 g of a colorless oily substance, 7-cyclohexyl-1-(1,3-dioxolan-2-ylmethyl)-4-methylquinolin-2(1H)-one.

Workup

  1. additionwas added
  2. filtrationThe insoluble material filtered off
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-b34bdd13118141ada97b019efdf12798
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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