Thionyl Chloride → HCID 69878366, compound

HRID 396961Notes

Reaction equation

HRID 396961 reaction equation
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:22]O)[N:14]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.S(Cl)([Cl:26])=O>>[ClH:26].[Cl:26][CH2:22][C:13]1[N:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]=[C:2]([NH2:1])[C:11]=2[N:12]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 9904568HCID 9904568, compound

Product 1

HCID 69878366HCID 69878366, compound

Procedure

4-Amino-1-phenylmethyl-1H-imidazo[4,5-c]quinoline-2-methanol (2.0 g; 0.0066 mol, Example 27) was added in small portions to thionyl chloride (10 mL). After stirring at room temperature for 30 min the product had crystallized from solution. The mixture was diluted with dry ether (75 mL). The solid was filtered from the mixture, washed with ether, and thoroughly dried. The product was used as such without further characterization or purification.

Workup

  1. customhad crystallized from solution
  2. additionThe mixture was diluted with dry ether (75 mL)
  3. filtrationThe solid was filtered from the mixture
  4. washwashed with ether
  5. customthoroughly dried
  6. customsuch without further characterization or purification

Sources & evidence

ORD record
ord-87959e0063ec45b99ee757eb7d847116
Source dataset
uspto-grants-2003_08
Patent number
US06608201B2

Reaction notes

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