反应详情

1-[1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl]propan-2-one (8 g, 28.4 mmol, Example 73) was suspended in ethanol (400 mL). Sodium borohydride (1.64 g, 43.3 mmol) was added and the reaction mixture was stirred at room temperature for about 2 hours. Methanol (about 20 mL) was added and stirring was continued over night. Water was added then the solvents were removed under vacuum. The residue was partitioned between methylene chloride and water. The methylene chloride layer was separated, dried over magnesium sulfate then concentrated under vacuum to give the desired product. The structure was confirmed by nuclear magnetic resonance spectroscopy.

1. stirringstirring
2. waitwas continued over night
3. customthe solvents were removed under vacuum
4. customThe residue was partitioned between methylene chloride and water
5. customThe methylene chloride layer was separated
6. dry with materialdried over magnesium sulfate
7. concentrationthen concentrated under vacuum