反应详情

温度

150 °C

100 g (0.445 mol) of 4-(trifluoromethyl)bromobenzene, 120 g (2.22 mol) of sodium methoxide, and 300 ml of methanol were mixed together in a pressurized reaction vessel, followed by stirring for 6 hr at 150° C. under tight sealing. The resulting reaction mixture was poured into water, followed by extraction with n-hexane. The resulting organic layer was washed with water, followed by drying with magnesium sulfate anhydride and removal of the solvent by distillation. The obtained residue was purified by distillation, thereby obtaining 49 g (0.278 mol) of 4-(trifluoromethyl)anisole (yield: 62.6%).

1. customThe resulting reaction mixture
2. extractionfollowed by extraction with n-hexane
3. washThe resulting organic layer was washed with water
4. dry with materialby drying with magnesium sulfate anhydride and removal of the solvent by distillation
5. distillationThe obtained residue was purified by distillation