Hexane → HCID 18172437, compound

Participants

Reaction Conditions

Reaction Steps

Phosphorus pentachloride (58.557 g, 281.2 mmol) was added in portions to a solution of 4-benzyloxy-N-[2-(3-methoxyphenyl)ethyl]benzamide (59.775 g, 165.4 mmol) in 1,2-dichloroethane (500 ml) at 0° C. under N2. The resulting reaction was stirred at 0° C. for 30 min, then refluxed for 18 hr. After cooling to rt, hexane (1200 ml) was added and the resulting suspension was cooled to 0° C. The solvent was decanted off from the oil that separated and the remaining oil was dried in vacuo to give 54.56 g (87% yield) of orange residue.

Provenance & Evidence