Sodium borohydride → HCID 4279899, compound

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (10.874 g, 287.3 mmol) was added in small portions to a solution of 1-(4-benzyloxyphenyl)-6-methoxy-3,4-dihydroisoquinoline (54.56 g, 143.6 mmol) in MeOH (600 ml) at 0° C. The reaction mixture was stirred at 0° C. for 1 hr, then quenched by the dropwise addition of H2O (20 ml). The resulting mixture was concentrated in vacuo to a volume of about 100 ml. The solid that separated was collected to give 35.926 g (72% yield) of white solid.

Provenance & Evidence