反应详情

1-[1-(4-Benzyloxyphenyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoroethanone (26.97 g, 61.1 mmol) was hydrogenated using 10% Pd/C (1.000 g) in EtOH (300 ml) at an initial pressure of 44 psi (˜300,000 Pa) at rt for 6 hr. The reaction mixture was filtered through a pad of Celite to remove the catalyst and the filtrate was evaporated in vacuo to give 18.98 g (88% yield) of white solid.

1. customat rt
2. customfor 6 hr
3. filtrationThe reaction mixture was filtered through a pad of Celite
4. customto remove the catalyst
5. customthe filtrate was evaporated in vacuo