Ammonium formate → HCID 12085944, compound

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Reaction Steps

A mixture of 1-[1-(4-benzyloxyphenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoroethanone (0.144 g, 0.35 mmol), ammonium formate (0.441 g, 7.00 mmol), and 20% Pd(OH)2/C (0.100 g) in MeOH (50 ml) was refluxed under N2 for 1.5 hr, then filtered through Celite. The filtrate was evaporated in vacuo to a yellow residue that was suspended in a mixture of H2O (15 ml) and saturated NaHCO3 solution (15 ml), then extracted with CHCl3 (4×15 ml). The combined organic extracts were dried over MgSO4 and concentrated in vacuo to give 0.115 g of colorless oil. Purification by flash chromatography, eluting with hexane:EtOAc (8:2) gave 0.100 g (89% yield) of colorless oil.

Provenance & Evidence