Dichloromethane → HCID 18172445, compound

HRID 397094Notes

Reaction equation

HRID 397094 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([C:13]1[S:14][CH:15]=[CH:16][N:17]=1)[N:8]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:7][CH2:6]2.C(Cl)Cl>CO.C(Cl)Cl>[C:18]1([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([OH:2])[CH:4]=3)[CH:9]2[C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 18172395HCID 18172395, compound

Product 1

HCID 18172445HCID 18172445, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared by analogy to Example 48 except that 6-methoxy-2-phenyl-1-thiazol-2-yl-1,2,3,4-tetrahydroisoquinoline was used instead of 6-methoxy-1-(4-methoxy-phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline, and neat CH2Cl2 to 10% MeOH/CH2Cl2 was used as eluent for flash chromatography purification.

Workup

  1. customwas used as eluent for flash chromatography purification

Sources & evidence

ORD record
ord-36c07d01d7444e3ea6609e7301311fc9
Source dataset
uspto-grants-2003_08
Patent number
US06608203B2

Reaction notes

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