Dichloromethane → HCID 18172483, compound

HRID 397096Notes

Reaction equation

HRID 397096 reaction equation
[C:1]12([CH:11]3[C:20]4[C:15](=[CH:16][C:17]([O:21]C)=[CH:18][CH:19]=4)[CH2:14][CH2:13][N:12]3[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C(Cl)Cl>CO.C(Cl)Cl>[C:1]12([CH:11]3[C:20]4[C:15](=[CH:16][C:17]([OH:21])=[CH:18][CH:19]=4)[CH2:14][CH2:13][N:12]3[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 18172439HCID 18172439, compound

Product 1

HCID 18172483HCID 18172483, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared by analogy to Example 48 except that 1-adamantan-1-yl-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline was used instead of 6-methoxy-1-(4-methoxy-phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline, and neat CH2Cl2 to 10% MeOH/CH2Cl2 was used as eluent for flash chromatography purification.

Workup

  1. customwas used as eluent for flash chromatography purification

Sources & evidence

ORD record
ord-ba363a37683b4db3ab53a0e04d3e4305
Source dataset
uspto-grants-2003_08
Patent number
US06608203B2

Reaction notes

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