Boron tribromide → HCID 9819159, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,2,2-trifluoro-1-[7-methoxy-4-(4-methoxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone (1.74 g, 4.76 mmol, see Example 82) in CH2Cl2 (100 ml) cooled to 0° C. was added BBr3 as a 1.0 M solution in CH2Cl2 (14.28 ml, 14.28 mmol) in a dropwise manner. The reaction mixture was stirred at 0° C. for 60 minutes, the ice bath removed, and stirring continued at RT for 90 minutes. MeOH (10 ml) was added to the reaction and stirring was continued at RT for 10 minutes. The reaction mixture was concentrated in vacuo and purified by flash chromatography (Biotage, SiO2, 25-40% EtOAc/hexanes) to give the title product (1.36 g, 4.03 mmol, 85% yield).

Provenance & Evidence